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Updated: Apr 22, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
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Revolutionizing Mg-based guided bone regeneration mesh derived from endogenous dentoalveolar bone augmentation.

Shiyuan Li1, Mingyu You1, Hao Zheng1

  • 1National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite, School of Materials Science and Engineering, Shanghai Jiao Tong University, 200240, Shanghai, PR China.

Bioactive Materials
|April 21, 2026
PubMed
Summary

This study introduces a novel magnesium-alloy mesh for guided bone regeneration (GBR), enhancing alveolar bone repair. The coated mesh promotes natural bone growth, offering a promising solution for complex bone defects.

Keywords:
Alveolar bone reconstructionBone augmentationGuided bone regenerationLPBF customized Mg-Alloy mesh

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Surgery

Background:

  • Alveolar bone regeneration is complex due to anatomical and functional challenges.
  • Customized bone grafts using CAD and AM show promise for alveolar defects.
  • Biodegradable magnesium (Mg) alloys are ideal for guided bone regeneration (GBR) but suffer from rapid degradation.

Purpose of the Study:

  • To develop a customized Mg-alloy GBR mesh with a strontium-doped octacalcium phosphate (SrOCP) coating.
  • To regulate degradation and enhance osteogenesis for improved alveolar bone regeneration.
  • To evaluate the efficacy of the developed mesh in a beagle model for alveolar defect repair.

Main Methods:

  • Digital modeling and laser powder bed fusion (LPBF) were used to fabricate the customized Mg-alloy mesh.
  • A strontium-doped octacalcium phosphate (SrOCP) coating was applied to the mesh.
  • The mesh was implanted in beagle models to repair alveolar defects and its performance was assessed over 12 weeks.

Main Results:

  • The Mg-alloy GBR mesh demonstrated controlled degradation and significant promotion of endogenous bone regeneration via the PI3K/Akt pathway.
  • Effective repair of 15 mm × 8 mm × 5 mm alveolar defects was achieved without additional membranes or bone substitutes.
  • The new bone volume fraction reached 86.89% at 12 weeks, indicating strong osteogenic capability.

Conclusions:

  • A biodegradable LPBF Mg-alloy mesh with SrOCP coating presents a promising strategy for alveolar bone regeneration.
  • This approach facilitates guided bone regeneration, addressing limitations of current Mg-alloy applications.
  • The developed GBR system shows potential for clinical translation in treating complex alveolar bone defects.