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Transanal Irrigation in Functional Constipation: Long-term Results From an Italian National Study.

Ezio Falletto1, Jacopo Martellucci2,3, Piera Rossitti4

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Summary

Transanal irrigation significantly improves quality of life and bowel function for functional constipation patients over 24 months. This safe and effective treatment offers long-term benefits for chronic constipation management.

Keywords:
Functional constipationLong-termQuality of lifeReal-world evidenceTransanal irrigation

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Area of Science:

  • Gastroenterology
  • Medical Devices
  • Patient Quality of Life

Background:

  • Functional constipation is a chronic condition impacting patient well-being.
  • Effective long-term management strategies are needed.

Purpose of the Study:

  • To evaluate the long-term (12 and 24 months) effectiveness and safety of transanal irrigation for functional constipation.
  • To assess improvements in patient satisfaction, quality of life, and constipation severity.

Main Methods:

  • A prospective, observational study involving 216 adults with functional constipation across 13 Italian centers.
  • Patients used a transanal irrigation system and completed validated questionnaires.
  • Outcomes included patient satisfaction, quality of life, constipation severity, symptom occurrence, and safety over 24 months.

Main Results:

  • Significant improvements in patient satisfaction (p < 0.001) and quality of life (p < 0.001) were sustained over 24 months.
  • Constipation severity (Wexner score) decreased significantly (p < 0.001) and symptoms declined.
  • The treatment showed a good safety profile with low discontinuation rates and no serious adverse events reported.

Conclusions:

  • Transanal irrigation is an effective and safe long-term treatment for functional constipation.
  • The therapy significantly enhances bowel function, reduces symptoms, and improves quality of life.
  • This study provides initial evidence supporting its sustained benefits.