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Spatially Compartmentalized DNA Nanodevices for Extra-/Intracellularly Synergistically Modulating Cancer Cell

Yanjun Liu1, Ruixue Chang1, Xiuping Li1

  • 1Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China.

ACS Applied Bio Materials
|April 21, 2026
PubMed
Summary

Researchers developed a novel DNA nanodevice that targets cancer cells by responding to specific biomarkers. This advanced nanodevice selectively delivers chemotherapy drugs and inhibits cancer cell growth, offering a new approach to precision therapeutics.

Keywords:
DNA nanodevicec-Met degradationspatial compartmentalizationstimulus-responsivetargeted drug delivery

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Area of Science:

  • Biotechnology
  • Nanomedicine
  • Cancer Therapeutics

Background:

  • Stimulus-responsive DNA nanodevices are promising for targeted therapies.
  • Effective spatial regulation of cellular behavior via allosteric switching remains a challenge.

Purpose of the Study:

  • To construct a DNA nanodevice (GA-Tc/DOX) that responds to cancer cell microenvironments.
  • To achieve spatially regulated inhibition of cancer cell proliferation and migration.

Main Methods:

  • Designed a DNA nanodevice to detect elevated K+ and ATP levels.
  • Engineered the device for selective c-Met receptor binding and degradation.
  • Utilized G-quadruplex dimerization for transferrin receptor (TfR)-mediated doxorubicin (DOX) delivery.

Main Results:

  • The GA-Tc/DOX nanodevice demonstrated selective membrane anchoring and inhibition of c-Met signaling.
  • K+-induced G-quadruplex formation facilitated targeted DOX delivery via TfR.
  • The nanodevice significantly suppressed cancer cell proliferation and migration.

Conclusions:

  • The GA-Tc/DOX nanodevice establishes a paradigm for spatially regulated cancer cell intervention.
  • This nanodevice offers a sophisticated tool for advancing precision therapeutics through synergistic membrane-intracellular modulation.