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Trifloxystrobin-Induced Neurotoxicity in Wistar Rats: Biomarkers of Oxidative Stress, Cholinergic Dysfunction, and

Hanen Chaabani1,2, Asma Mnassri1,3, Siwar Rich1,2

  • 1Laboratory of Research on Biologically Compatible Compounds, LR01SE17, University of Monastir, Faculty of Dental Medicine, 5019, Monastir, Tunisia.

Neurotoxicity Research
|April 21, 2026
PubMed
Summary

No abstract available in PubMed .

Keywords:
AChE ActivityDNA DamageHistopathological AlterationsLipid DysregulationOxidative StressTrifloxystrobin

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Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
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