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The selfish ribosome.

Mart Krupovic1, Eugene V Koonin2

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The ribosome, crucial for protein synthesis, may have originated as a symbiotic partner. It evolved into a dominant cellular component, potentially exhibiting selfish characteristics.

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Area of Science:

  • Molecular Biology
  • Origin of Life Studies
  • Evolutionary Biology

Background:

  • The ribosome is essential for protein synthesis and a major cellular energy consumer.
  • Understanding the ribosome's evolutionary origins is key to comprehending early cellular life.

Purpose of the Study:

  • To propose a novel hypothesis for the origin and evolution of the ribosome.
  • To explore the ribosome's role as a mutualistic symbiont in the early RNA world.
  • To reframe the ribosome's current function within a framework of evolutionary takeover.

Main Methods:

  • Theoretical modeling of early life evolution.
  • Comparative analysis of ribosomal structure and function.
  • Hypothesis-driven research integrating biochemistry and evolutionary theory.

Main Results:

  • The ribosome may have begun as a symbiont aiding RNA replication.
  • The transition to the RNA-protein world led to dependence on the ribosome for replication proteins.
  • The ribosome's evolution suggests a 'takeover' of cellular resources for its own propagation.

Conclusions:

  • The ribosome's origin as a mutualistic symbiont is proposed.
  • The ribosome's current dominance can be explained by an evolutionary takeover.
  • The ribosome exhibits characteristics of a selfish, yet essential, cellular symbiont.