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Glycated CD59, a Novel Biomarker for Gestational Diabetes
Michelle Toth Castillo1, Shauntina Drayton Powell1, Amy Biermann1
1Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; Boston, MA, USA.
Endocrine Reviews
|April 21, 2026
Summary
Gestational diabetes mellitus (GDM) screening faces challenges with current oral glucose tolerance tests. A novel biomarker, plasma glycated CD59 (pGCD59), shows promise as an accurate and well-tolerated alternative for GDM diagnosis.
Area of Science:
- Reproductive Medicine
- Endocrinology
- Immunology
Background:
- Gestational diabetes mellitus (GDM) is a significant public health concern, increasing risks for maternal and infant health complications.
- Current GDM diagnosis relies on oral glucose tolerance tests (OGTTs), which are inconvenient and difficult for universal screening.
- Effective GDM treatment can mitigate adverse pregnancy outcomes, underscoring the need for improved diagnostic methods.
Purpose of the Study:
- To introduce and review the discovery, development, and clinical validation of plasma glycated CD59 (pGCD59) as a novel biomarker for GDM.
- To highlight the potential of pGCD59 as a sensitive, accurate, and well-tolerated alternative to current GDM screening methods.
Main Methods:
- Clinical validation of plasma glycated CD59 (pGCD59) as a biomarker through six human studies.
- Evaluation of pGCD59's performance in screening, diagnosing, and monitoring GDM.
Main Results:
- Plasma glycated CD59 (pGCD59) has been discovered, developed, and clinically validated across multiple human studies.
- pGCD59 demonstrates potential as a reliable biomarker for GDM detection and management.
Conclusions:
- pGCD59 represents a promising new biomarker for gestational diabetes mellitus screening and diagnosis.
- This biomarker offers a potentially more accessible and patient-friendly alternative to conventional OGTTs, addressing current screening limitations.
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