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Effectiveness and safety of ocrelizumab in relapsing-onset multiple sclerosis: A nationwide real-world study from
Marianna Vitková1, Jarmila Szilasiová1, Miriam Fedičová1
1Clinic of Neurology, Medical Faculty, Pavol Jozef Šafárik University, Louis Pasteur University Hospital, Košice, Slovakia.
Background:
Ocrelizumab (OCR) is a high-efficacy anti-CD20 monoclonal antibody approved for multiple sclerosis (MS) treatment. This nationwide real-world study evaluated the effectiveness and safety of OCR in patients with relapsing-onset MS (ROMS) in Slovakia.
Methods:
This multicenter retrospective study included 499 patients with ROMS treated between January 2019 and January 2024. Outcomes included annualized relapse rate (ARR), confirmed disability progression (6mCDP), MRI activity, NEDA-3, and safety parameters.
Results:
During a mean follow-up of 2.4 years, ARR decreased from 1.1 to 0.04; 6mCDP occurred in 7.1% of patients, and NEDA-3 was achieved in 75.5%. OCR was well tolerated with infusion-related reactions (12.2%) and infections (<6%) as the most common adverse events.
Conclusions:
OCR demonstrated high effectiveness and a favorable safety profile in routine clinical practice, supporting early initiation of high-efficacy therapy in relapsing-onset MS.
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