Recent advances in microbial biohybrids based oxygen delivery systems

Area of Science:

• Biomedical Engineering
• Drug Delivery Systems
• Microbiology

Background:

• Oxygen (O2) has critical therapeutic uses, driving innovation in O2 delivery platforms.
• Microbial carriers like bacteria and microalgae generate O2 under light, offering prolonged therapeutic effects.
• Challenges include immune responses to microbes and limited O2 production due to microbial viability.

Purpose of the Study:

• To review advancements in microbial biohybrids for oxygen delivery.
• To summarize strategies for constructing enhanced O2 delivery systems.
• To provide insights for future research and clinical translation.

Main Methods:

• Comprehensive literature review of microbial biohybrids for O2 delivery.
• Systematic summary of construction strategies: physical encapsulation, surface modification, co-delivery.
• Analysis of challenges and future research directions.

Main Results:

• Microbial biohybrids can overcome limitations of traditional microbial carriers for O2 delivery.
• Pharmaceutical decoration strategies enhance O2 generation, duration, and biocompatibility.
• Innovative approaches include encapsulation, surface functionalization, and combination therapies.

Conclusions:

• Microbial biohybrids represent a promising strategy for advanced oxygen delivery systems.
• Further research is needed to optimize design and facilitate clinical translation.
• These systems hold potential for improved therapeutic efficacy in various clinical settings.