Related Experiment Video
Updated: Apr 23, 2026
Quantifying Arms and Legs Contributions during Repetitive Electrically-Assisted Sit-To-Stand Exercise in Paraplegics: A Pilot Study
Published on: November 11, 2022
Feasibility and Validity of a Remotely Administered 30-Second Sit-to-Stand in People with Multiple Sclerosis
Parisa Najafi1, Louise Declerck1, Trinh L T Huynh2
1Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL.
Objectives:
To evaluate the feasibility and validity of the remotely administered 30-second Sit-to-Stand (30s STS) test as a measure of lower-extremity function in a convenience sample of people with multiple sclerosis (MS).
Design:
Cross-sectional observational study.
Setting:
Remote, videoconference-based assessments conducted via Zoom.
Participants:
Convenience sample of adults with MS (n=541) and healthy controls (n=74).
Interventions:
Not applicable.
Main Outcome Measures:
Number of 30s STS repetitions, completion rate, and correlations of 30s STS performance with cognitive and patient-reported outcome measures.
Results:
The remote 30s STS test was completed by 498 participants with MS (92%) and all 74 healthy controls (100%) with no adverse events. The 30s STS performance was significantly lower in the MS than in healthy controls (10.4 vs 14.0 repetitions; P<.001; d=-0.75), and this group difference remained significant after adjusting for group differences in age, sex, and marital status. The 30s STS repetitions were strongly associated with mobility disability (patient-determined disease step: r=-0.56) and walking limitations (12-Item Multiple Sclerosis Walking Scale: r=-0.57); moderately associated with physical health (12-Item Short Form Health Survey Physical Component Summary: r=0.41) and processing speed (Symbol Digit Modalities Test: r=0.34); and weakly associated with symptoms, mental status, verbal learning and memory (California Verbal Learning Test-Second Edition), and physical activity in MS.
Conclusions:
The remotely administered 30s STS appears to be a feasible and valid measure of lower-extremity physical function in stable, relapse-free individuals with MS and may be a useful outcome for telerehabilitation research in this population.
