Cutaneous T-Cell Lymphoma-Like Eruption from Trimethoprim-Sulfamethoxazole

Area of Science:

• Dermatology
• Immunology
• Pathology

Background:

• Cutaneous pseudolymphoma presents as a diverse group of benign skin conditions mimicking lymphoma.
• Causes include idiopathic factors, drugs, infections, or foreign materials, presenting diagnostic challenges.
• It can manifest as B-cell, T-cell, or mixed types, necessitating careful clinicopathologic correlation.

Purpose of the Study:

• To report a unique case of cutaneous T-cell lymphoma-like eruption.
• To investigate the association with trimethoprim-sulfamethoxazole in a patient with systemic lupus erythematosus.
• To present comprehensive clinical, histopathologic, immunophenotypic, and genetic findings.

Main Methods:

• Case report detailing clinical presentation.
• Histopathologic examination of skin biopsy.
• Immunophenotypic analysis to determine cell lineage.
• Genetic analysis for specific markers.

Main Results:

• A 55-year-old female with systemic lupus erythematosus developed a T-cell lymphoma-like eruption.
• The eruption was attributed to trimethoprim-sulfamethoxazole.
• Detailed findings from histopathology, immunophenotyping, and genetic analysis were documented.

Conclusions:

• Trimethoprim-sulfamethoxazole can induce a T-cell lymphoma-like cutaneous pseudolymphoma.
• Systemic lupus erythematosus patients may be susceptible to drug-induced pseudolymphoma.
• Accurate diagnosis requires integrated clinicopathologic and molecular evaluation.