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Defining estimands in anaesthesia clinical trials: a scoping review and framework

Gethmini A Siriwardena1, Sarah Luu2, Rukshala K Gunaratne1

  • 1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.

British Journal of Anaesthesia
|April 21, 2026
PubMed
Summary

Estimands are rarely used in anesthesia trials, hindering outcome interpretation. A new tool aids in identifying and managing intercurrent events for clearer anesthesia research.

Keywords:
ICH E9(R1)anaesthesia clinical trialsclinical trial designestimand frameworkintercurrent eventsperioperative medicinerandomised controlled trialscoping review

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