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[Recent advances in non-coding RNA-mediated PI3K/AKT/mTOR signaling pathway regulation involved in triple-negative

Zhu Huang1,2, Wen-Jing Li1, Zi-Juan Song1

  • 1Innovation Center of Targeted Development of Medicinal Resources, School of Life Sciences and Food Engineering, Anqing Normal University, Anqing 246133, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|April 21, 2026
PubMed

Insights

Triple-negative breast cancer (TNBC) is aggressive, lacking effective treatments. Non-coding RNAs (ncRNAs) like miRNAs, lncRNAs, and circRNAs regulate the PI3K/AKT/mTOR pathway, offering potential therapeutic targets for TNBC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Triple-negative breast cancer (TNBC) exhibits high metastasis, poor prognosis, and mortality.
  • The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is frequently activated in TNBC, contributing to therapeutic resistance.

Purpose of the Study:

  • To review the roles of non-coding RNAs (ncRNAs) in regulating the PI3K/AKT/mTOR pathway in TNBC.
  • To explore potential therapeutic strategies targeting ncRNAs for TNBC treatment.

Main Methods:

  • Literature review of studies on ncRNAs, PI3K/AKT/mTOR pathway, and TNBC.
  • Analysis of molecular mechanisms involving microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) in TNBC.

Main Results:

  • ncRNAs act as oncogenes or tumor suppressors by modulating the PI3K/AKT/mTOR pathway in TNBC.
  • Specific miRNAs, lncRNAs, and circRNAs and their targets involved in TNBC progression were identified.

Conclusions:

  • Dysregulation of the PI3K/AKT/mTOR pathway by ncRNAs is crucial in TNBC development.
  • Targeting ncRNAs presents a promising avenue for developing precise and effective TNBC therapies.

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