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Updated: Apr 23, 2026

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[Research progress on protein succination modification in cancer]

Qian-Qian Ju1, Cheng Sun1

  • 1NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Key Laboratory of Neuroregeneration of Ministry of Education, Jiangsu Key Laboratory of Tissue Engineering and Neuroregeneration, Co-innovation Center of Neuroregeneration, Key Laboratory of Neuroregeneration of Nantong University, Nantong 226001, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|April 21, 2026
PubMed

Insights

Cancer involves metabolic changes, where fumarate accumulation drives tumor growth and immune evasion. Protein succination modification, a key process, offers new therapeutic targets for improved cancer treatment.

Area of Science:

  • Biochemistry
  • Oncology
  • Molecular Biology

Background:

  • Metabolic dysregulation is a key characteristic of cancer.
  • Mutations in tricarboxylic acid (TCA) cycle enzymes lead to oncometabolite accumulation.
  • Oncometabolites like fumarate impact tumor initiation, progression, and immune evasion.

Purpose of the Study:

  • To review the role of protein succination modification in cancer metabolism and immune evasion.
  • To explore the clinical applications of targeting protein succination modification.

Main Methods:

  • Literature review of studies on fumarate accumulation and protein succination.
  • Analysis of the mechanisms by which fumarate affects cellular processes.
  • Examination of the link between succination modification and tumor microenvironment.

Main Results:

  • Fumarate accumulation, often due to fumarate hydratase (FH) inactivation, alters mitochondrial function, DNA repair, and protein activity.
  • Fumarate modifies cysteine residues on proteins, forming S-(2-succinyl)cysteine (2SC) modifications.
  • Protein succination modification is implicated in tumor initiation, progression, and immune evasion.

Conclusions:

  • Protein succination modification is a critical factor in cancer development and immune evasion.
  • Targeting succination modification presents a promising strategy for novel cancer therapies.
  • Further research into metabolic interventions for succination modification could enhance cancer treatment outcomes.

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