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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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Related Experiment Video

Updated: Apr 23, 2026

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model
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Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Published on: January 1, 2017

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[Exercise improves osteoporosis through bone-fat crosstalk].

Yi-Lin Ou1, Rui Peng1, Shao-Jie Xu1

  • 1School of Graduate, Guangzhou Sport University, Guangzhou 510620, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|April 21, 2026
PubMed
Summary
This summary is machine-generated.

Exercise can improve osteoporosis by regulating bone and lipid metabolism. This review explores how exercise influences bone-fat crosstalk and its molecular mechanisms for treating osteoporosis.

Related Experiment Videos

Last Updated: Apr 23, 2026

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model
08:53

Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model

Published on: January 1, 2017

8.8K

Area of Science:

  • Bone Biology
  • Metabolic Diseases
  • Exercise Physiology

Background:

  • Osteoporosis (OP) is a metabolic bone disease linked to imbalanced bone and lipid metabolism.
  • Bone and lipid crosstalk, regulated by signaling pathways and cellular interactions, is vital for metabolic equilibrium.
  • Exercise is a promising intervention for OP, impacting bone and adipose tissues.

Purpose of the Study:

  • To review research on bone-fat crosstalk in osteoporosis.
  • To summarize exercise's effects on bone-fat crosstalk mechanisms.
  • To provide a theoretical basis for exercise-based OP prevention and treatment.

Main Methods:

  • Literature review of studies on bone-fat crosstalk.
  • Analysis of signaling pathways (Wnt/β-catenin, BMP, MAPK, PPARγ, Notch, Hedgehog, PI3K/Akt).
  • Examination of cellular interactions in the bone marrow microenvironment.

Main Results:

  • Exercise influences bone tissue, adipose tissue, and bone marrow adipose tissue.
  • Exercise modulates key signaling pathways involved in bone-fat crosstalk.
  • Exercise demonstrates potential in improving osteoporosis through these mechanisms.

Conclusions:

  • Exercise plays a significant role in regulating bone-fat crosstalk.
  • Understanding these mechanisms can guide exercise interventions for osteoporosis.
  • Further research is needed to fully elucidate exercise's molecular impact on bone-fat crosstalk.