Retinoic Acid and Long Noncoding RNAs Crosstalk: Implications for Neuronal Differentiation and Diseases

Area of Science:

• Molecular Biology
• Genetics
• Developmental Biology

Background:

• Retinoic acid (RA), a vitamin A metabolite, is a key signaling molecule controlling cell functions via nuclear receptors.
• Long noncoding RNAs (lncRNAs) are regulatory RNAs impacting gene expression through diverse mechanisms.
• Both RA signaling and lncRNA networks are implicated in aging and associated diseases.

Purpose of the Study:

• To review the mechanisms of RA-mediated modulation of lncRNA expression.
• To highlight the role of RA-lncRNA interactions in development, disease, and aging.
• To explore the therapeutic potential of targeting this crosstalk.

Main Methods:

• Literature review focusing on transcriptional and post-transcriptional regulation.
• Analysis of studies investigating RA-lncRNA interactions in various biological contexts.
• Synthesis of information on RNA-based therapeutic strategies.

Main Results:

• RA influences lncRNA expression through transcriptional and post-transcriptional regulation.
• The interplay between RA and lncRNAs is crucial for cell differentiation, tissue development, and disease pathogenesis.
• RA-lncRNA crosstalk is involved in aging and age-related diseases.

Conclusions:

• The intricate relationship between RA and lncRNAs is fundamental to normal development and disease processes.
• Understanding RA-lncRNA crosstalk opens avenues for novel RNA-based therapeutic interventions.
• Targeting RA-lncRNA interactions may offer promising treatments for age-related diseases.