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Visualizing glutathione levels in adipose tissue: a CBD aryl ether thiolysis-activated ESIPT probe for obesity
Liya Jing1,2,3,4, Lijuan Shan1, Ziming Shen1
1School of Pharmacy, Nantong University, Nantong 226001, China. jinlongli@ntu.edu.cn.
Chemical Communications (Cambridge, England)
|April 22, 2026
Abstract:
We report a cyanobenzoxadiazole (CBD) based fluorescent probe 1 for selective glutathione (GSH) detection via thiolysis and ESIPT. It exhibits high sensitivity, tunable Kd, and biocompatibility, enabling imaging of endogenous GSH and distinguishing stromal vascular fraction (SVF) cells in high-fat-diet mouse models for obesity research.
