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Updated: Apr 23, 2026

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Three Pilot Randomized Controlled Trials Evaluating a Persuasive Health Communication Intervention for Adult

Roland C Merchant1, Melissa A Clark2, Michael P Carey3

  • 1Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, US.

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|April 22, 2026
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Summary

A new health communication intervention effectively encouraged emergency department patients to accept HIV and hepatitis C virus testing, even after initial refusal. This intervention shows promise for increasing screening rates for these infections.

Keywords:
HIV testingemergency servicehepatitis Chospitalpersuasive communication

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Area of Science:

  • Public Health
  • Infectious Disease Prevention
  • Health Communication

Background:

  • Emergency department (ED) HIV and hepatitis C virus (HCV) testing success is limited by patient refusal.
  • Evidence-based interventions are needed to overcome reluctance to accept ED-based HIV/HCV testing.
  • A persuasive health communication intervention (PHCI) was developed to address this reluctance.

Purpose of the Study:

  • To evaluate the effectiveness of a PHCI in increasing acceptance of HIV/HCV testing among ED patients who initially declined screening.
  • To compare the performance of the PHCI delivered via video versus in-person by a counselor.

Main Methods:

  • Three pilot randomized controlled trials (pRCTs) enrolled adult ED patients who declined HIV/HCV screening.
  • Participants were randomized to receive either the PHCI (video or in-person) or a control video.
  • The primary outcome was post-intervention acceptance of HIV/HCV testing.

Main Results:

  • The PHCI video showed a trend towards increased testing acceptance compared to the control video (29.6% vs. 10.7%, p=0.08).
  • In-person PHCI delivery showed a trend towards lower testing acceptance than the control video (10.0% vs. 26.7%, p=0.09) in one pRCT.
  • In-person PHCI delivery resulted in higher testing acceptance than the PHCI video in another pRCT (48.3% vs. 34.5%, p=0.29).

Conclusions:

  • The PHCI demonstrates potential for increasing HIV/HCV screening acceptance in the ED setting.
  • Both in-person and video delivery methods of the PHCI show promise in persuading patients to undergo testing.
  • Further research is warranted to optimize the delivery and impact of this intervention.