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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
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Association Between miR-146a rs2910164 Polymorphism and Tuberculosis Susceptibility: A Comprehensive Meta-Analysis.

Mohammad Yousef Alikhani1,2, Fatemeh Khoobbakht3, Salman Khazaei4

  • 1Infectious Disease Research Center, Avicenna Institute of Clinical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.

International Journal of Molecular and Cellular Medicine
|April 22, 2026
PubMed
Summary

This meta-analysis found no significant link between the miR-146a rs2910164 genetic variant and tuberculosis susceptibility. Further large-scale studies are needed to confirm this null association.

Keywords:
Tuberculosisgenetic susceptibilitymeta-analysismiR-146amicroRNA polymorphismrs2910164

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Area of Science:

  • Genetics
  • Immunology
  • Epidemiology

Background:

  • Previous studies suggest a link between the miR-146a rs2910164 polymorphism and tuberculosis (TB) susceptibility.
  • Existing evidence is contradictory, lacking a definitive consensus on this association.

Purpose of the Study:

  • To systematically evaluate the relationship between the miR-146a rs2910164 single nucleotide polymorphism (SNP) and TB risk.
  • To provide a comprehensive meta-analysis of available case-control studies.

Main Methods:

  • Systematic literature search of PubMed, Web of Science, Scopus, and ISI databases up to April 2024.
  • Inclusion of eight case-control studies comprising 6363 individuals (2904 TB patients, 3459 controls).
  • Quantitative synthesis using pooled odds ratios (ORs) and 95% confidence intervals (CIs); heterogeneity assessed by chi-square and I² statistics.

Main Results:

  • No significant association was found between the rs2910164 polymorphism and tuberculosis susceptibility across all genetic models (e.g., dominant model: OR = 0.971, 95% CI: 0.884-1.068).
  • High heterogeneity (I² > 70%) was observed in most genetic models.
  • No evidence of publication bias was detected.

Conclusions:

  • The current meta-analysis does not support a significant association between the miR-146a rs2910164 G>C variant and tuberculosis susceptibility.
  • Larger, well-designed studies are required to validate this null finding.