Cytoreductive Radical Prostatectomy in Oligometastatic Prostate Cancer: Single-Centre Experience.

Area of Science:

• Urology
• Oncology
• Surgical Oncology

Background:

• Oligometastatic prostate cancer (OPC) presents a treatment challenge.
• Multimodal therapy is often employed for OPC management.

Purpose of the Study:

• To evaluate oncological outcomes, functional recovery, and patient satisfaction after cytoreductive radical prostatectomy (CRP) for OPC.
• To assess the safety and feasibility of CRP in a tertiary care setting.

Main Methods:

• Prospective analysis of 12 patients with OPC (≤5 bone lesions, no visceral metastases) undergoing open retropubic CRP.
• Patients received neoadjuvant and adjuvant androgen deprivation therapy (ADT) and targeted radiotherapy.
• Outcomes included continence, erectile function, and biochemical recurrence (BCR).

Main Results:

• Mean follow-up was 25 months, with no BCR observed.
• 83% achieved continence at 1 year; potency was regained in 100% of nerve-sparing cases within 12 months.
• 83% of patients reported complete satisfaction with CRP.

Conclusions:

• CRP is a safe and feasible component of multimodal therapy for carefully selected OPC patients.
• The procedure demonstrated acceptable perioperative morbidity and encouraging oncological and functional outcomes.
• CRP may play a role in comprehensive disease control for OPC.