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Related Experiment Video

Updated: Apr 23, 2026

Translational Orthotopic Models of Glioblastoma Multiforme
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Prognostic Stratification and Subtyping of Glioblastoma Using Transient Receptor Potential Channels.

Runfeng Sun1, Long Zhu1,2, Zhichao Lu1,3

  • 1Cardio-Cerebral Vascular Disease Prevention and Treatment Innovation Center, Donghai County People's Hospital, Lianyungang, Jiangsu, China.

Human Mutation
|April 22, 2026
PubMed
Summary

A new seven-gene prognostic score (TRPRS) accurately predicts glioblastoma patient outcomes and guides therapy. This transient receptor potential (TRP) channel-based tool identifies therapeutic vulnerabilities in glioblastoma (GBM).

Keywords:
IFNGR2TRP channelsglioblastomaimmune infiltrationimmunotherapy responsemultiomics integrationprognostic model

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Area of Science:

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background:

  • Transient receptor potential (TRP) channels are implicated in glioblastoma (GBM) pathogenesis.
  • Their prognostic significance and therapeutic potential in GBM are not well understood.

Purpose of the Study:

  • To develop and validate a prognostic model for glioblastoma (GBM) based on TRP channel-related genes.
  • To explore the therapeutic implications of this model in GBM.

Main Methods:

  • A compendium of 522 TRP-related genes was curated.
  • Differential expression analysis and LASSO-Cox regression identified a seven-gene prognostic score (TRPRS) in The Cancer Genome Atlas Glioblastoma cohort (TCGA-GBM).
  • The TRPRS model was validated in three independent cohorts, with integrated multiomics and functional assays.

Main Results:

  • The TRPRS robustly stratified GBM patients into high- and low-risk groups with distinct overall survival (AUC = 0.72-0.81).
  • High TRPRS was associated with specific genomic alterations, diminished T-cell infiltration, and predicted resistance to multiple therapies.
  • IFNGR2 knockdown suppressed glioma cell proliferation and NF-κB signaling.

Conclusions:

  • The TRPRS serves as a reliable tool for prognostication and therapy guidance in GBM.
  • TRP signaling represents a potential therapeutic vulnerability in glioblastoma.