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Nanoporous Materials in Biomedical Research: Progress and Potential.

Fangli Gao1, Jianming Xing2, Chengzhong Yu2

  • 1School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, People's Republic of China.

International Journal of Nanomedicine
|April 22, 2026
PubMed
Summary
This summary is machine-generated.

This review explores nanoporous nanomaterials for biomedical applications, detailing their interactions with biological systems and uses in drug delivery, tissue engineering, and cancer therapy. It also discusses challenges and future directions for these advanced materials.

Keywords:
biomedical applicationbiomedical fieldsdrug delivery systemsinterdisciplinary areamechanistic interactionnanoporous materials

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Nanoporous materials exhibit unique properties driving biomedical applications like drug delivery and tissue engineering.
  • Existing reviews often focus narrowly on synthesis or specific uses, lacking a holistic, mechanism-oriented perspective.

Purpose of the Study:

  • To provide an integrated, mechanism-oriented overview of nanoporous nanomaterials for biomedical applications.
  • To systematically summarize interactions between nanoporous materials and biological systems at multiple levels.
  • To analyze challenges and future trends in the field.

Main Methods:

  • Classification and definition of nanoporous materials.
  • Systematic review of interactions at molecular, cellular, and tissue levels.
  • Analysis of applications in drug/gene delivery, tissue repair, cancer therapy, and theranostics.
  • Critical evaluation of biosafety, stability, biodegradation, and clinical translation challenges.

Main Results:

  • Nanoporous materials show significant promise across diverse biomedical fields.
  • Understanding nanoporosity is key to governing biological responses.
  • Key applications include smart drug delivery, regenerative medicine, and advanced cancer therapies.
  • Significant challenges remain for clinical translation, including biosafety and immune interactions.

Conclusions:

  • Nanoporous nanomaterials offer versatile platforms for advanced biomedical applications.
  • Further research is needed to address safety, stability, and clinical translation hurdles.
  • This review serves as a foundational reference for researchers entering this interdisciplinary field.