Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Nucleolus02:55

The Nucleolus

8.6K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
8.6K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.5K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.5K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.0K
3.0K
Condensins02:15

Condensins

3.7K
Condensins are large protein complexes that use ATP to fuel the assembly of chromosomes during mitosis. They transform the tangled, shapeless mass of post-interphase DNA into individualized chromosomes by compacting, organizing, and segregating chromosomal DNA.
The plant and animal cells contain two types of condensin complexes—condensin I and condensin II. Both complexes have five subunits: two SMC (Structural Maintenance of Chromosomes) subunits, a kleisin subunit, and two HEAT-repeat...
3.7K
Cellular Injury IlI: Cellular Death01:11

Cellular Injury IlI: Cellular Death

12
Cell death is the irreversible loss of cellular structure and function, representing the final stage of severe injury. It plays a key role in both normal physiology and disease.Types of Cell DeathThe two main types are necrosis and apoptosis, though others like necroptosis and pyroptosis also exist.Necrosis:Necrosis is an unregulated form of cell death caused by severe injury such as trauma, toxins, or ischemia. It is characterized by cell swelling, membrane loss, rupture, and leakage of...
12

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Different modes of engagement with the nucleosome acidic patch yield distinct functional outcomes.

Nucleic acids research·2026
Same author

Different modes of engagement with the nucleosome acidic patch yield distinct functional outcomes.

bioRxiv : the preprint server for biology·2026
Same author

Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake.

eLife·2026
Same author

A needed nomenclature for nucleosomes.

Molecular cell·2025
Same author

Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage.

Nature communications·2025
Same author

Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Apr 23, 2026

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
08:55

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

10.1K

Nucleolar expansion: A biomolecular condensate mortality timer.

J Ignacio Gutierrez1, Jessica K Tyler1

  • 1Weill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, NY 10065, USA.

Geromedicine
|April 22, 2026
PubMed
Summary
This summary is machine-generated.

The nucleolus, a key cell component, expands with age due to biophysical changes. This expansion may drive cellular aging by altering its function and stability.

Keywords:
Nucleolusagingcondensateslifespan extensionlongevitymortality timer

More Related Videos

Chemical Dimerization-Induced Protein Condensates on Telomeres
08:52

Chemical Dimerization-Induced Protein Condensates on Telomeres

Published on: April 12, 2021

2.5K
Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
06:48

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells

Published on: January 5, 2024

5.3K

Related Experiment Videos

Last Updated: Apr 23, 2026

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
08:55

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

10.1K
Chemical Dimerization-Induced Protein Condensates on Telomeres
08:52

Chemical Dimerization-Induced Protein Condensates on Telomeres

Published on: April 12, 2021

2.5K
Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
06:48

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells

Published on: January 5, 2024

5.3K

Area of Science:

  • Cell Biology
  • Aging Research
  • Biophysics

Background:

  • The nucleolus is the largest membraneless organelle, crucial for ribosome biogenesis and protein regulation.
  • Nucleolar expansion is a common feature of aging in eukaryotes, but its role as a cause or consequence is debated.

Purpose of the Study:

  • To review recent literature on age-driven changes in nucleolar condensation.
  • To discuss how these biophysical alterations impact nucleolar function and cellular longevity.

Main Methods:

  • Literature review of studies on nucleolar biophysics and aging.
  • Analysis of age-associated changes in nucleolar size, dynamics, and viscoelasticity.
  • Examination of transitions in nucleolar condensate states (liquid-like to gel-like/amyloid-like).

Main Results:

  • Age-driven biophysical changes in the nucleolus include altered size, dynamics, and viscoelasticity.
  • These changes can lead to transitions from liquid-like to denser, gel-like or amyloid-like states.
  • Remodeling of nucleolar compartmentalization and partitioning affects ribosome biogenesis and rDNA stability.

Conclusions:

  • Age-associated biophysical changes in the nucleolus may drive cellular aging.
  • Understanding these changes is critical for insights into nucleolar function and longevity.
  • Nucleolar condensation dynamics offer potential targets for aging interventions.