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Non-invasive MRI of choroid plexus vascular function.

Peiying Liu1, Lori Donaldson1, Beini Hu1

  • 1Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.

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|April 22, 2026
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Summary
This summary is machine-generated.

We developed a non-invasive MRI method to measure choroid plexus (ChP) vascular elasticity. This technique reveals age-related declines in ChP vascular function, offering a new tool for clinical assessment.

Keywords:
BOLDagingchoroid plexuselasticityfunctional MRIvasculature

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Area of Science:

  • Neuroimaging
  • Vascular Biology
  • Cerebrospinal Fluid Dynamics

Background:

  • The choroid plexus (ChP) is crucial for cerebrospinal fluid (CSF) production and the blood-CSF barrier.
  • ChP vascular integrity is vital for brain waste clearance, particularly in aging and neurodegenerative diseases.
  • Current methods for assessing ChP vascular function are primarily postmortem, limiting in-vivo studies.

Purpose of the Study:

  • To propose and validate a non-invasive MRI approach for assessing choroid plexus vascular elasticity in living subjects.
  • To investigate the potential of BOLD MRI with vasoactive challenges for evaluating ChP vascular function.
  • To establish a clinically feasible tool for monitoring ChP vascular health.

Main Methods:

  • Development of a non-invasive MRI technique to detect signal changes related to ChP vascular volume alterations.
  • Utilized BOLD MRI with hypercapnia (CO2 inhalation) as a vasoactive challenge to assess ChP vascular elasticity.
  • Explored gas-free methods including intermittent breath modulation and resting-state BOLD fMRI for ChP elasticity assessment.

Main Results:

  • Demonstrated that BOLD MRI with hypercapnia can effectively evaluate ChP vascular elasticity.
  • Observed a specific signal localization within brain ventricles, corresponding to ChP abundance.
  • Successfully detected age-related reductions in ChP vascular elasticity using the developed MRI technique.
  • Confirmed the feasibility of gas-free MRI methods for assessing ChP vascular elasticity.

Conclusions:

  • The proposed non-invasive MRI technique provides a reliable method for evaluating choroid plexus vascular elasticity.
  • This approach can detect age-related changes in ChP vascular function.
  • The technique holds promise as a clinically applicable tool for assessing ChP vascular health in various conditions.