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Updated: Apr 23, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Performance-enhancing asymmetric catalysis unlocks tuning without rebuilding
Zihang Deng1, Jeffrey N Johnston1
1Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235.
Abstract:
Performance-Enhancing Asymmetric Catalysis (PEAC) is a new strategy for catalyst optimization. Rather than relying on the slow, resource- and time-intensive covalent modification of chiral ligands, this approach "tunes" a single ligand using a library of simple, achiral acids. The counterions produced upon ion pair formation perturbate the catalyst's chiral pocket through non-covalent interactions to significantly improve enantioselectivity. This method creates an adaptable chiral ligand system that is well-suited for rapid, high-throughput screening and catalyst discovery.
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