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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
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Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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Association between menopausal status and physical function: a systematic review and meta-analysis.

Pedro R S Macêdo1, Sabrina G G F Macêdo1, Ananília Regina Silva Cavalcante2

  • 1Department of Physical Therapy, Federal University of Rio Grande do Norte, Natal, Brazil.

Climacteric : the Journal of the International Menopause Society
|April 22, 2026
PubMed
Summary
This summary is machine-generated.

Menopausal status significantly impacts physical function. Premenopausal and perimenopausal women exhibit stronger physical capabilities compared to postmenopausal women, highlighting the need for targeted health strategies during menopause.

Keywords:
Menopauseagingmeta-analysisphysical functionsystematic reviewwomen

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Area of Science:

  • Reproductive Endocrinology
  • Gerontology
  • Physical Therapy

Background:

  • Menopause is a significant biological transition in women's lives.
  • Physical function changes are often associated with aging and hormonal shifts.
  • Understanding the impact of menopausal status on physical function is crucial for women's health.

Purpose of the Study:

  • To systematically review and meta-analyze the association between menopausal status and physical function.
  • To synthesize evidence from observational studies on this relationship.

Main Methods:

  • Systematic review and meta-analysis following PRISMA guidelines.
  • Searches conducted across major scientific databases (PubMed, Cochrane Library, SciELO, LILACS, Web of Science).
  • Meta-analysis performed using RevMan 5 software on data from 26 observational studies.

Main Results:

  • 80.8% of included studies found significant associations between menopausal status and physical function.
  • Premenopausal and perimenopausal women demonstrated stronger handgrip strength compared to postmenopausal women (unadjusted and adjusted analyses).
  • Premenopausal women also showed better performance in strength, balance, and self-reported physical function tests than postmenopausal women.

Conclusions:

  • The menopausal transition is a critical period associated with a decline in physical function.
  • Healthcare strategies should be implemented to support women's physical health during this phase.
  • Further research on interventions to mitigate physical decline during menopause is warranted.