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Updated: Apr 23, 2026
09:59
A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
Published on: September 16, 2017
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Discriminating migraine aura from transient ischemic attack using MRI-based oxygen metabolism mapping: A preliminary
P Pernot1, A Bani-Sadr2,3, E Ong1
1Department of Stroke Medicine, Neurological Hospital P. Wertheimer, Université Claude Bernard Lyon 1, Hospices Civils de Lyon, Bron, France.
Headache
|April 22, 2026
Summary
Migraine aura (MA) can mimic stroke. New MRI techniques measuring oxygen extraction fraction (OEF) show higher OEF in MA patients compared to TIA patients, aiding diagnosis.
Area of Science:
- Neurology
- Radiology
- Neuroimaging
Background:
- Migraine aura (MA) is a frequent mimic of acute stroke.
- Clinical differentiation between MA and transient ischemic attack (TIA) is challenging.
- Routine MRI may not reliably distinguish MA from TIA.
Purpose of the Study:
- To evaluate the utility of cerebral oxygen metabolism maps in differentiating MA from TIA.
- To investigate the impact of oxygen extraction fraction (OEF) on differential diagnosis.
Main Methods:
- Retrospective diagnostic accuracy study (2012-2024) at Lyon Stroke Center.
- Included patients with emergency MRI and final diagnosis of MA or TIA.
- Utilized dynamic susceptibility-weighted (DSC) perfusion MRI post-processing for OEF estimation.
Main Results:
- 53 patients included (39 MA, 14 TIA).
- Significantly higher OEF in MA patients compared to TIA patients (median change +15% vs -8%, p<0.001).
- OEF ratio showed high diagnostic accuracy (AUC 0.89) and was an independent predictor of MA.
Conclusions:
- Migraine aura is associated with a focal increase in OEF during the acute phase.
- OEF mapping using DSC perfusion MRI may assist in differentiating MA from TIA.
- Further research is required to confirm the clinical utility of OEF mapping.
Keywords:
magnetic resonance imagingmigraine auraoxygen metabolismretrospective studiestransient ischemic attackMore Related Videos
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