Recent advances in chiral nanomaterials for tumor theranostics

Area of Science:

• Nanotechnology
• Materials Science
• Oncology

Background:

• Chiral nanomaterials exhibit unique optical activity and bio-recognition capabilities.
• These properties hold significant potential for modulating cellular behavior in tumor theranostics.

Purpose of the Study:

• To systematically review recent advancements in chiral nanomaterials for tumor diagnosis and therapy.
• To highlight the role of chirality in enhancing precision and efficacy in cancer theranostics.

Main Methods:

• Elaboration on construction strategies for nanoscale molecular chirality.
• Focus on applications in tumor imaging and biomarker detection using chiroptical signals.
• Summary of therapeutic strategies including immunotherapy, chemodynamic therapy, and drug delivery.

Main Results:

• Chiral nanomaterials enable sensitive detection of trace biomarkers via chiroptical signal changes.
• Applications span tumor imaging, immunotherapy, chemodynamic therapy, photodynamic/sonodynamic therapy, and drug delivery systems.
• Construction strategies amplify molecular chirality to the nanoscale for enhanced functionality.

Conclusions:

• Chirality is a key design dimension for improving tumor theranostics precision and efficacy.
• Chiral nanomaterials show great potential for next-generation cancer therapy.
• Current challenges and future perspectives in the field are discussed.