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Related Experiment Video

Updated: Apr 30, 2026

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Published on: August 21, 2019

Virus-Like Nanoparticles for Vaccine Development and Drug Delivery.

De-Feng Li¹, Mei-Feng Yang², Ning-Ning Yue¹

¹Department of Gastroenterology, Shenzhen People's Hospital (the Second Clinical Medical College, Jinan University, the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.

Reviews in Medical Virology

|April 22, 2026

Summary

This summary is machine-generated.

Virus-like nanoparticles (VLPs) are versatile nanomaterials for advanced therapies. This review covers VLP design, applications in drug delivery and gene therapy, and their potential in theranostics.

Keywords:

drug delivery systems theranostics vaccine virus‐like nanoparticles

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Last Updated: Apr 30, 2026

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Published on: February 10, 2022

Area of Science:

Nanotechnology
Biotechnology
Materials Science

Background:

Virus-like nanoparticles (VLPs) are self-assembled protein nanomaterials derived from viral capsid proteins.
VLPs offer high biocompatibility, biodegradability, uniform structure, and controlled assembly.
They are recognized for their potential in diagnostics and therapies, including immunotherapy and drug delivery.

Purpose of the Study:

To provide a comprehensive overview of Virus-like nanoparticles (VLPs).
To discuss recent advances in engineered VLPs for various therapeutic applications.
To highlight the potential of VLPs as efficient delivery vehicles for theranostic applications.

Main Methods:

Review of fundamental aspects of VLPs, including types, structures, and immune mechanisms.
Analysis of VLP expression and purification methods.
Summarization of research on engineered VLPs for drug delivery, gene therapy, and immunology.

Main Results:

VLPs are versatile platforms for drug delivery, gene therapy, and immunotherapy.
Engineered VLPs show promise as chimaeric vectors for enhanced delivery.
Successful VLP-based drug delivery systems demonstrate theranostic potential.

Conclusions:

Virus-like nanoparticles (VLPs) represent a complex and versatile therapeutic platform.
VLPs can be engineered for efficient delivery in gene therapy and drug delivery systems.
VLPs offer significant potential for advanced theranostic applications by combining viral and non-viral delivery methods.