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Scalable Nanoedge Interfaces for Robust Intracellular Electrophysiology in Cardiomyocytes.
Haoran Gong1, Jilin Zheng1, Qiji Ma1
1Department of Chemistry, Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials, ZJU-Hangzhou Global Scientific and Technological Innovation Center, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Nano Letters
|April 22, 2026
Summary
Researchers developed a cost-effective nanoedge-enhanced electroporation (NEEE) device for high-quality intracellular recordings. This new method improves cardiac electrophysiology research by optimizing cell-electrode coupling and electroporation.
Area of Science:
- Cardiovascular Research
- Biomedical Engineering
- Cellular Electrophysiology
Background:
- Cardiac electrophysiology is vital for understanding heart disease.
- Current advanced devices for intracellular recordings are often expensive.
- There is a need for cost-effective solutions for high-quality electrophysiological recordings.
Purpose of the Study:
- To develop a low-cost, scalable device for high-quality intracellular recordings.
- To enhance cell-electrode coupling and electroporation for improved electrophysiological measurements.
- To investigate the impact of nanoedge geometry on recording quality and duration.
Main Methods:
- Development of a nanoedge-enhanced electroporation (NEEE) device compatible with microfabrication.
- Utilizing a scalable well-array structure with nanoedges.
- Regulating nanoedge dimensions to optimize the cell-electrode interface and electroporation.
Main Results:
- The NEEE device enables cost-effective, high-quality intracellular recordings.
- Nanoedges facilitate tight cell-electrode coupling and enhance electroporation efficiency.
- Adjustable nanoedge dimensions allow optimization for superior and long-term recordings.
Conclusions:
- The NEEE device significantly improves intracellular recordings through biointerface geometry regulation.
- This technology offers a novel approach for advancing cardiac electrophysiology research.
- The scalable and cost-effective nature of the NEEE device facilitates broader application.
