Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electrochemical Systems01:24

Electrochemical Systems

169
Electrochemical systems provide a fascinating insight into the dynamic interplay of charged species within various phases. One notable example is the interaction between a membrane permeable to K⁺ ions but not to Cl⁻ ions, separating an aqueous KCl solution from pure water. As K⁺ ions diffuse through the membrane, they generate net charges on each phase, leading to a potential difference between them.Similarly, when a piece of Zn is immersed in an aqueous ZnSO₄ solution,...
169
Electrochemical Cells01:28

Electrochemical Cells

348
Electrochemical cells are systems that convert chemical energy into electrical energy or use electrical energy to drive chemical reactions. They consist of two electrodes in contact with an electrolyte, where redox reactions enable electron transfer. Most electrochemical cells include two half-cells connected by an external wire for electron flow and a salt bridge for ion flow. The salt bridge contains an electrolyte solution and maintains charge neutrality by allowing ions—not...
348
Thermal and Photochemical Electrocyclic Reactions: Overview01:26

Thermal and Photochemical Electrocyclic Reactions: Overview

2.1K
Electrocyclic reactions are reversible reactions. They involve an intramolecular cyclization or ring-opening of a conjugated polyene. Shown below are two examples of electrocyclic reactions. In the first reaction, the formation of the cyclic product is favored. In contrast, in the second reaction, ring-opening is favored due to the high ring strain associated with cyclobutene formation.
2.1K
Electrochemistry: Overview01:04

Electrochemistry: Overview

2.9K
Electrochemistry is the branch of chemistry that studies the relationship between electrical quantities and chemical reactions, particularly oxidation and reduction. Oxidation is the loss of electrons from a substance, whereas reduction refers to the gain of electrons. A substance with a strong electron affinity is called an oxidizing agent (oxidant), and a reducing agent (reductant) is a species that donates electrons. Oxidation and reduction processes are pivotal to electrochemical reactions,...
2.9K
Processes at Electrodes01:30

Processes at Electrodes

95
The electrode interacts with ions in the electrolyte solution at its interface. The rate of oxidation and reduction depends on the speed at which electrons can transfer through this interface. As ions attach to or leave the electrode surface, the electrode acquires a charge, and an electrical potential forms across the interface, making the process more difficult to reach equilibrium. The charge on the electrode affects the local ion concentrations in the solution, though thermal motion...
95

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct CO<sub>2</sub> Reduction to CO with an Fe<sub>4</sub>S<sub>4</sub>-Based Coordination Polymer.

Journal of the American Chemical Society·2026
Same author

Unlocking Interfacial Catalytic Halogen Atom Transfer at Ag Electrodes with Brønsted Acids.

Journal of the American Chemical Society·2026
Same author

Regenerative Electroactive Self-Assembled Layers from Reversible Non-Covalent Interactions.

Journal of the American Chemical Society·2025
Same author

Unlocking Mesoscopic Disorder in Graphitic Carbon with Spectroelectrochemistry.

Angewandte Chemie (International ed. in English)·2024
Same author

Competitive Valerate Binding Enables RuO<sub>2</sub>-Mediated Butene Electrosynthesis in Water.

Journal of the American Chemical Society·2024
Same author

Catalytic, Spectroscopic, and Theoretical Studies of Fe<sub>4</sub>S<sub>4</sub>-Based Coordination Polymers as Heterogenous Coupled Proton-Electron Transfer Mediators for Electrocatalysis.

Journal of the American Chemical Society·2024
Same journal

Gas-Responsive Metal-Organic Frameworks for Adaptive Thermal Energy Storage with Tunable Charge-Discharge Temperatures.

Journal of the American Chemical Society·2026
Same journal

Engineering a Thiamine-Dependent Benzoylformate Decarboxylase for Stereodivergent Radical C(sp<sup>3</sup>)-C(sp<sup>3</sup>) Bond Formation.

Journal of the American Chemical Society·2026
Same journal

Accelerated Directional Proton-Coupled Electron Transfer Enabled by Intrinsic Dipole Field in Biomimetic α-Helical Structure.

Journal of the American Chemical Society·2026
Same journal

Alternating Current-Driven Hydrogen Isotope Labeling of Aliphatic Amines Using 1,3-Propanedithiol as an Efficient Hydrogen Atom Transfer Reagent.

Journal of the American Chemical Society·2026
Same journal

Two-Dimensional van der Waals Polar Metal MoOBr<sub>2</sub>.

Journal of the American Chemical Society·2026
Same journal

Negatively Curved Chiral Bilayer Nanographene.

Journal of the American Chemical Society·2026
See all related articles

Related Experiment Video

Updated: Apr 23, 2026

Antifouling Self-assembled Monolayers on Microelectrodes for Patterning Biomolecules
10:27

Antifouling Self-assembled Monolayers on Microelectrodes for Patterning Biomolecules

Published on: August 25, 2009

10.9K

Electrode-Orthogonal Non-Covalent Self-Assembly Programs Microenvironments around Molecular Electrocatalysts.

Gregory Gorobets1, Deepak Badgurjar1, Ashok Tate1

  • 1Department of Chemistry, University of Chicago, Chicago, Illinois 60637, United States.

Journal of the American Chemical Society
|April 22, 2026
PubMed
Summary
This summary is machine-generated.

We developed a catalyst design using self-assembly to control molecular active sites and microenvironments for efficient electrosynthesis in water. This strategy enhances oxygen reduction for hydrogen peroxide production and allows catalyst recovery.

More Related Videos

Self-standing Electrochemical Set-up to Enrich Anode-respiring Bacteria On-site
05:29

Self-standing Electrochemical Set-up to Enrich Anode-respiring Bacteria On-site

Published on: July 24, 2018

7.1K
Electrochemical Preparation of Poly3,4-Ethylenedioxythiophene Layers on Gold Microelectrodes for Uric Acid-Sensing Applications
10:48

Electrochemical Preparation of Poly3,4-Ethylenedioxythiophene Layers on Gold Microelectrodes for Uric Acid-Sensing Applications

Published on: July 28, 2021

3.7K

Related Experiment Videos

Last Updated: Apr 23, 2026

Antifouling Self-assembled Monolayers on Microelectrodes for Patterning Biomolecules
10:27

Antifouling Self-assembled Monolayers on Microelectrodes for Patterning Biomolecules

Published on: August 25, 2009

10.9K
Self-standing Electrochemical Set-up to Enrich Anode-respiring Bacteria On-site
05:29

Self-standing Electrochemical Set-up to Enrich Anode-respiring Bacteria On-site

Published on: July 24, 2018

7.1K
Electrochemical Preparation of Poly3,4-Ethylenedioxythiophene Layers on Gold Microelectrodes for Uric Acid-Sensing Applications
10:48

Electrochemical Preparation of Poly3,4-Ethylenedioxythiophene Layers on Gold Microelectrodes for Uric Acid-Sensing Applications

Published on: July 28, 2021

3.7K

Area of Science:

  • Electrochemistry
  • Catalysis
  • Materials Science

Background:

  • Electrosynthesis of hydrogen peroxide (H2O2) from oxygen (O2) is crucial for sustainable chemical production.
  • Controlling the catalyst's microenvironment is key to enhancing reaction efficiency and selectivity.
  • Anthraquinone catalysts are effective but often limited by accessibility in aqueous solutions.

Purpose of the Study:

  • To introduce a novel catalyst design strategy using non-covalent self-assembly for enhanced electrosynthesis.
  • To demonstrate molecular control over active sites and the microenvironment simultaneously.
  • To improve the efficiency of hydrogen peroxide electrosynthesis in water under neutral conditions.

Main Methods:

  • Designing anthraquinone-functionalized amphiphiles that self-assemble at polarized electrodes.
  • Utilizing electrostatic and van der Waals interactions for *in situ* catalyst assembly.
  • Employing a model system of H2O2 electrosynthesis from O2 under neutral conditions.

Main Results:

  • Self-assembled catalysts created a hydrophobic microenvironment, increasing intermediate basicity by 3 pKa units.
  • Enhanced O2 reduction activity compared to control catalysts in the bulk solution.
  • Achieved high catalytic rate of 924 mol H2O2 mol_cat⁻¹ h⁻¹ on high-surface-area electrodes.
  • Demonstrated catalyst reversibility, recovery, and reusability.

Conclusions:

  • Electrode-orthogonal non-covalent self-assembly is a versatile strategy for enhancing electrocatalysis.
  • Programming microenvironments around catalytic sites via self-assembly offers molecular tunability.
  • This approach enables efficient and sustainable electrosynthesis in aqueous media.