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Infective endocarditis and precision medicine: A narrative review
Julián Orlando Casallas-Barrera1,2, Laura Marcela Castilla Gómez1,3, Paola Andrea Castro Ochoa1,3
1Department of Critical Care and Intensive Care Medicine, Fundación Clínica Shaio, Bogotá, Colombia.
Science Progress
|April 22, 2026
Summary
Precision medicine can improve early detection and treatment for infective endocarditis (IE). This approach uses risk profiling, diagnostics, and tailored therapies for better patient outcomes in IE management.
Area of Science:
- Cardiology
- Genomics
- Public Health
Background:
- Infective endocarditis (IE) presents significant global health challenges due to high morbidity and mortality.
- Current management strategies necessitate enhanced methods for early detection and effective treatment.
- Precision medicine offers a novel paradigm for addressing complex diseases like IE.
Purpose of the Study:
- To explore the potential of precision medicine in improving infective endocarditis diagnosis and treatment.
- To synthesize current literature on precision medicine applications in IE.
- To highlight the benefits of individualized therapeutic strategies for IE patients.
Main Methods:
- A systematic literature search was conducted across PubMed, Scopus, and Embase.
- Key findings from relevant studies were identified and synthesized.
- A narrative review approach was employed to consolidate the information.
Main Results:
- Precision medicine enables comprehensive risk profiling, integrating genetic, comorbidity, and lifestyle factors.
- It facilitates the development of point-of-care diagnostics for timely IE detection.
- Patient-specific treatment strategies can be tailored for improved therapeutic efficacy.
Conclusions:
- Precision medicine represents a promising framework for advancing infective endocarditis care.
- It holds the potential to significantly enhance diagnostic timeliness and treatment individualization in IE.
- Further integration of precision medicine approaches is recommended for IE management.
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