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Published on: January 7, 2019
Infective endocarditis and precision medicine: A narrative review
Julián Orlando Casallas-Barrera1,2, Laura Marcela Castilla Gómez1,3, Paola Andrea Castro Ochoa1,3
1Department of Critical Care and Intensive Care Medicine, Fundación Clínica Shaio, Bogotá, Colombia.
Abstract:
Infective endocarditis (IE) remains a life-threatening condition with high global morbidity and mortality, demanding more effective strategies for early detection and management. Precision medicine offers a transformative approach, starting with comprehensive risk profiling that combines genetic predisposition, preexisting comorbidities, and lifestyle factors such as intravenous drug use and oral hygiene. This paradigm extends to point-of-care diagnostics and culminates in targeted, patient-specific treatment strategies. To explore its potential in IE, we systematically searched PubMed, Scopus, and Embase, identifying and synthesizing key literature into a narrative review. Our findings highlight precision medicine as a promising framework to enhance timely diagnosis and support individualized therapeutic decision-making in IE.
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