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Updated: Apr 23, 2026

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase
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RIG-I-Adjuvanted Immunogen Elicited T-Cell Immunity Controls Trypanosoma cruzi, Chagasic Cardiomyopathy, and Left

Nandadeva Lokugamage1, Allison Wyrick1, Subhadip Choudhuri1

  • 1Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.

JACC. Basic to Translational Science
|April 22, 2026
PubMed

BCVR and BCV (bicistronic immunogen with and without RIG-I adjuvant) immunogens were designed in compliance with Food and Drug Administration guidelines. These immunogens were nontoxic, and highly effective in controlling the replication and persistence of Trypanosoma cruzi. Importantly, BCV/BCVR blocked the myocarditis, cardiac fibrosis, and left ventricular dysfunction that otherwise contribute to heart failure and sudden death in Chagas disease.

Keywords:
Chagas diseaseTrypanosoma cruziantibody and T cell responsebicistronic immunogenheart function

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