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Related Concept Videos

Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Related Experiment Video

Updated: Apr 23, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
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Integrated Multiomic Profiling Enhances Risk Stratification and Prognostication in Canine Osteosarcoma.

Anjali Garg1, Joshua D Mannheimer2, Heather Gardner3

  • 1National Cancer Institute Bethesda United States.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|April 22, 2026
PubMed
Summary
This summary is machine-generated.

Osteosarcoma research in canines reveals MYC amplification as a poor prognostic indicator. Shared genetic alterations in DNA repair, metabolism, and cell cycle genes offer insights into this aggressive bone cancer for both dogs and humans.

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Area of Science:

  • Comparative oncology
  • Multiomic data analysis
  • Cancer genomics

Background:

  • Osteosarcoma is an aggressive bone cancer affecting dogs and humans.
  • Current treatments have stagnant outcomes due to disease complexity.
  • A need exists for novel prognostic biomarkers and therapeutic targets.

Purpose of the Study:

  • To present the first multiomic dataset from canine osteosarcoma.
  • To identify prognostic indicators and shared genetic alterations between canine and human osteosarcoma.
  • To explore relationships between the tumor microenvironment and genetic profiles.

Main Methods:

  • Creation of a multiomic dataset from a biobank of treatment-naïve canine osteosarcoma tumors.
  • Utilized a computational framework for individual dataset interrogation and integrated analysis.
  • Analyzed genomic, transcriptomic, and epigenomic data.

Main Results:

  • MYC amplification identified as a poor prognostic indicator in canine osteosarcoma.
  • Shared alterations in DNA damage repair, metabolism, and cell cycle genes noted between species.
  • Correlations found between tumor immune microenvironment, TP53 mutations, MYC/PTEN status, and DNA methylation.

Conclusions:

  • Osteosarcoma exhibits significant complexity requiring further investigation.
  • Identified potential prognostic biomarkers and druggable targets for osteosarcoma.
  • Comparative oncology approach provides valuable insights for both canine and human patients.