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Updated: Apr 24, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Imine Reductase-Catalyzed Asymmetric Synthesis of Pharmaceutically Relevant Amino-Indanes
Lu Chen1,2, Yu Li2, Mengting Zhang1,2
1Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Abstract:
Chiral amino-indanes are valuable pharmaceutical intermediates, yet their efficient asymmetric synthesis remains challenging. In this study, enzymatic reduction of imines using enantiocomplementary IREDs enabled the synthesis of chiral amino-indanes. Furthermore, a one-pot, two-step cascade reaction combining trimethyl borate-promoted imine formation with IRED-catalyzed imine reduction was established to produce chiral amino-indanes with 87-99% ee values via a continuous fed-batch strategy, providing environmentally friendly and economical access to these pharmaceutically relevant compounds.
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