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The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
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The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
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Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
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Updated: Apr 24, 2026

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CiliaKB: A comprehensive knowledge base for cilia-associated genes.

Chun-Jie Liu1,2, Chao Zhang1, Wei Feng1

  • 1Zhanjiang Institute of Clinical Medicine, Central People's Hospital of Zhanjiang, Guangdong Medical University Zhanjiang Central Hospital, Zhanjiang, PR China.

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|April 22, 2026
PubMed
Summary
This summary is machine-generated.

Cilia dysfunction causes many disorders. CiliaKB is a new knowledge base providing researchers with curated data on cilia mechanisms and translational insights.

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Area of Science:

  • Cell Biology
  • Genetics
  • Biochemistry

Background:

  • Cilia are crucial cellular organelles involved in diverse biological processes.
  • Dysfunction of cilia is linked to numerous human diseases, highlighting the need for comprehensive research resources.

Purpose of the Study:

  • To introduce CiliaKB, a manually curated knowledge base.
  • To provide researchers with a centralized platform for accessing cilia-related mechanistic data.
  • To facilitate the mining of translational clues for cilia-related disorders.

Main Methods:

  • Manual curation of scientific literature.
  • Data extraction focusing on cilia structure, function, and disease association.
  • Development of a user-friendly knowledge base interface.

Main Results:

  • CiliaKB offers a one-stop platform for cilia research.
  • The knowledge base contains manually curated mechanistic data.
  • Researchers can efficiently access information and identify translational opportunities.

Conclusions:

  • CiliaKB serves as a valuable resource for the cilia research community.
  • The platform supports deeper understanding of cilia dysfunction and related diseases.
  • CiliaKB aids in the discovery of potential therapeutic targets for ciliopathies.