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Updated: Apr 24, 2026

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Screening for amyloidosis before aortic valve elective replacement: results from the SAVER study

Isabel Mattig1,2,3,4,5, Katrin Wrede-Wihl5,6,7, Selin Sökmen1,2,5

  • 1Deutsches Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine, Charitéplatz 1, Berlin 10117, Germany.

European Journal of Preventive Cardiology
|April 22, 2026
PubMed

Insights

The SAVER study developed a screening tool to detect cardiac amyloidosis (CA) in patients with aortic stenosis (AS). This holistic approach identifies patients at risk, enabling earlier intervention for better outcomes.

Area of Science:

  • Cardiology
  • Medical Diagnostics
  • Genetics

Background:

  • Concomitant aortic stenosis (AS) and cardiac amyloidosis (CA) significantly worsen heart failure and reduce life expectancy.
  • Early detection of CA in AS patients is crucial for preventing disease progression but remains an unmet clinical need.

Purpose of the Study:

  • To establish a simple and effective screening method for cardiac amyloidosis (CA) in patients with aortic stenosis (AS).
  • To identify key predictors for CA in AS patients to facilitate early diagnosis and intervention.

Main Methods:

  • Prospective cohort study (SAVER) enrolling 1001 AS patients undergoing valve replacement (TAVI/SAVR).
  • Initial screening included CA-specific symptoms and history, followed by DPD scintigraphy or MRI for suspected cases.
  • Multiple-regression analysis identified predictors for CA risk, including male sex, carpal tunnel syndrome, spinal stenosis, and NT-proBNP.

Main Results:

  • 40% of enrolled patients (405/1001) were flagged for potential CA.
  • 17 cases (2%) of CA were confirmed through further diagnostics.
  • The optimized screening approach achieved an AUC of 0.88, indicating high diagnostic accuracy.

Conclusions:

  • The SAVER approach represents the first holistic screening method for CA in AS patients, considering multiorgan manifestations.
  • This validated screening tool can be implemented in clinical practice to prevent adverse outcomes associated with combined AS and CA.
Abstract

Keywords:
ATTRAmyloidosisAortic valve stenosisScreeningSurgical aortic valve replacementTranscatheter aortic valve implantation

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