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  1. Home
  3. Recognition-based Chiral Amplification Through Adaptive Locking.
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  3. Recognition-based Chiral Amplification Through Adaptive Locking.

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Recognition-Based Chiral Amplification through Adaptive Locking.

Yu-Dong Yang1, Jiaqi Liang2, Xingchen Jin1

  • 1Department of Chemistry, The University of Texas at Austin, 105 East 24th Street, Stop A5300, Austin, Texas 78712-1224, United States.

Journal of the American Chemical Society
|April 22, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

A new adaptive-locking chirality (ALC) strategy uses molecular organic cages (Cg) to control chiral amplification. This method stabilizes helical configurations, enhancing chiroptical signals for advanced materials.

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Area of Science:

  • Supramolecular Chemistry
  • Chirality Studies
  • Materials Science

Background:

  • Controlling chiral amplification in host-guest systems is challenging due to structural rigidity or flexibility issues.
  • Stable helicity is crucial for chiroptical induction, impacting circular dichroism (CD) and circularly polarized luminescence (CPL) responses.

Purpose of the Study:

  • To introduce a novel supramolecular-based adaptive-locking chirality (ALC) strategy for integrated chirality induction and helicity control.
  • To develop a molecular organic cage (Cg) capable of binding diverse chiral acids and stabilizing helical configurations.

Main Methods:

  • Utilized a flexible molecular organic cage (Cg) designed for binding multiple chiral guests.
  • Employed structural, spectroscopic, and kinetic analyses to monitor conformational changes and chirality immobilization.
  • Correlated NMR spectroscopic data (desymmetrization, Δν) with chiroptical performance (|g_lum|).

    • Main Results:

    • The ALC strategy successfully integrated chirality induction and helicity control within the Cg.
    • Conformational locking of the Cg occurred after binding four chiral acid guests, stabilizing a single helical configuration.
    • Observed a direct correlation between structural changes, enhanced chiroptical signals (|g_abs| up to 0.044, |g_lum| up to 0.012), and guest-dependent desymmetrization.

    Conclusions:

    • The Cg system demonstrates a guest-dependent progression from helix interconversion to immobilized chirality, leading to strong chiroptical signals.
    • Established a quantitative correlation between desymmetrization and luminescence properties, enabling predictive assessment of chiroptical performance.
    • The ALC strategy offers a general approach for designing high-performance chiroptical materials.