A Single-Stage Single-Coil Wireless Multi-Channel Adiabatic Supply Stimulation System for Multiple Source Current...

Area of Science:

• Biomedical Engineering
• Electrical Engineering
• Neuroscience

Background:

• Deep brain stimulation (DBS) requires precise current control for therapeutic efficacy.
• Existing wireless power solutions for multi-channel stimulation often face challenges with efficiency and complexity.
• Independent current regulation across multiple channels is crucial for advanced neuromodulation therapies.

Purpose of the Study:

• To present a novel single-stage, single-coil wireless multi-channel adiabatic supply stimulation (M-CASS) system.
• To demonstrate independent regulation of four constant stimulus currents without power-hungry current sources.
• To enhance AC-to-stimulation efficiency in wireless adiabatic stimulation for deep brain stimulation applications.

Main Methods:

• Development of a wireless power distributor combined with an AC-DC quadruple-output current regulator.
• Implementation of a channel-optimized size control technique and a wide adaptive offset control scheme.
• Fabrication of the M-CASS system using a 2.72 mm² 0.25-μm CMOS process operating over a 6.78-MHz resonant link.

Main Results:

• The M-CASS system successfully generated four independently controlled adiabatic supplies and stimulus currents.
• A peak AC-to-stimulation efficiency of 82.2% was achieved when delivering four 2-mA currents.
• High efficiency (approx. 80%) was maintained even with varying impedances and currents across the four channels.

Conclusions:

• The M-CASS system offers a compact and energy-efficient solution for multiple-source current-steering (MSCS) deep brain stimulation.
• Independent control of multiple stimulus channels via a single wireless link is feasible and efficient.
• This technology advances the development of sophisticated and less invasive neuromodulation devices.