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Updated: Apr 24, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
Published on: April 8, 2013
LVAD Therapy Improves Metabolic and Inflammatory State in the Heart
Pauline Mury1, Olina Dagher2, Pierre-Emmanuel Noly3
1Montreal Heart Institute, Research Center, Université de Montréal, Montréal, Québec, Canada; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada.
None:
Left ventricular assist devices remain a major step forward for end-stage heart failure patients awaiting transplantation. We investigated the molecular basis of the longitudinal effect of left ventricular assist device implantation in both ischemic and nonischemic cardiomyopathy patients. The results revealed a common signature of 13 genes associated with glucocorticoid receptor overexpression pretransplantation, independent of the etiology. Four key molecular hub genes from this signature were highlighted, involved respectively in metabolic plasticity (PDK4), limited inflammation (FKBP5 and ZBTB16), and repair (FOXO3). It shows, however, that these pathways contribute to cardiac homeostasis.
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