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Updated: Apr 24, 2026

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides
Published on: July 14, 2015
Synergistic benefits of polysaccharide-essential trace element complexes via coordination: Unraveling the links among
Yueqin Li1, Ruonan Yan1, Shufeng He1
1State Key Laboratory for Quality and Safety of Agro-Products, Ningbo University, Ningbo 315211, China; College of Food Science and Engineering, Ningbo University, Ningbo 315800, China; Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, Ningbo University, Ningbo 315800, China.
Abstract:
Natural polysaccharides often exhibit limited bioactivity owing to high molecular weight and poor solubility. Coordination with essential trace elements (zinc, iron, and selenium) offers a promising strategy to overcome these limitations. This review consolidates recent advances in polysaccharide-essential trace element complexes, focusing on their preparation, structural characterization, and synergistic mechanisms underlying their enhanced bioactivities. Detailed transformations upon polysaccharide structures are elucidated by revealing the binding sites between the elements and polysaccharides using multiple analytical techniques. These complexes improved antioxidant effect by scavenging radicals, activating endogenous antioxidant enzymes, and modulating key signaling pathways. Crucially, polysaccharides enrich short-chain fatty acid-producing bacteria as prebiotics, while released trace elements support barrier integrity and reduce oxidative stress, jointly fostering a mutualistic host-microbiota cycle. This integrated strategy improves trace element bioavailability and amplifies antioxidant and anti-inflammatory effects compared to individual components. These findings provide a foundation for their rational design as functional food ingredients and nutraceuticals.
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