Related Experiment Video
Updated: Apr 24, 2026

Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches
Published on: September 5, 2025
Kidney neural diversity and blood pressure regulation: resolving controversies and guiding hypertension therapy
1Department of Hematology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China; National Key Laboratory of Immune Response and Immunotherapy, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Abstract:
The kidney receives innervation from 3 distinct neural populations: tyrosine hydroxylase-positive sympathetic nerves, acetylcholine-positive parasympathetic nerves, and calcitonin gene-related peptide (CGRP)-positive vagal sensory nerves. Activation of kidney parasympathetic nerves triggers acetylcholine release. Optogenetic activation of kidney vagal sensory neurons decreases blood pressure and heart rate, whereas selective activation of kidney parasympathetic nerves exerts no measurable impact on blood pressure and heart rate.
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