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Mechanisms responsible for pacemaker activity in human gastric muscles

Sung Jin Hwang1, Tamara McErlain1, Rowena Seaton-Kelly1

  • 1Department of Physiology & Cell Biology, Reno School of Medicine Reno, University of Nevada, Reno, Nevada, USA.

The Journal of Physiology
|April 22, 2026
PubMed
Summary

This study reveals two distinct pacemaker regions in the human gastric antrum, with a higher-frequency pacemaker dominating gastric motility. The research details the ionic mechanisms, including calcium channels and release, that drive slow waves and peristalsis.

Keywords:
ANO1Ca2+ handlinggastric antrumgastric motilityinterstitial cells of Cajalslow waves

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