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A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
Published on: January 12, 2018
[A retrospective study of the impact of interpregnancy interval on preterm birth]
1Department of Maternal & Child and Adolescent Health, School of Public Health, Guangxi Medical University, Nanning 530021, China Liuzhou Maternity and Child Healthcare Hospital, Liuzhou 545001, China.
Objective: To explore the impact of interpregnancy interval (IPI) after a singleton live birth on preterm birth based on natural IPI data. Methods: Data were obtained from the Guangxi Population Health Information Business Application Platform. The analysis included women with two consecutive singleton deliveries between 2018 and 2023 from 81 medical institutions in Nanning City, Guangxi Zhuang Autonomous Region. Maternal demographic characteristics and delivery outcome data were collected. The association between IPI and preterm birth was assessed using logistic regression model, with subgroup analyses stratified by maternal age, mode of delivery, and preterm birth (all in the previous pregnancy). Additionally, a restricted cubic spline model was applied to examine the dose-response relationship between IPI and the risk of preterm birth. Results: A total of 39 434 women with two consecutive singleton pregnancies and deliveries were included in this study. Of these, 2 055 (5.2%) experienced a preterm birth in the subsequent delivery. Compared with an IPI of 18-23 months, the risk of preterm birth was significantly increased by 90% (OR=1.90, 95%CI: 1.53-2.33) for IPI <6 months and by 21% (OR=1.21, 95%CI: 1.04-1.41) for IPI of 6-11 months. This significantly elevated risk associated with short IPIs was observed across most subgroups. Among women with an IPI of ≥36 months, those who delivered vaginally had a 30% (OR=1.30, 95%CI: 1.04-1.63) increased risk of preterm birth. Restricted cubic spline analysis revealed an L-shaped dose-response relationship between IPI and the risk of preterm birth. The lowest risk was observed with IPIs ranging from 16 to 27 months. Conclusions: A short IPI is a risk factor for preterm birth. When providing preconception medical services across different populations, greater emphasis should be placed on assessing maternal age, prior pregnancy, and delivery history. Additionally, postpartum care should include personalized guidance to maintain an optimal IPI, thereby reducing the risk of preterm birth and improving maternal and infant health outcomes.
Objective: To explore the impact of interpregnancy interval (IPI) after a singleton live birth on preterm birth based on natural IPI data. Methods: Data were obtained from the Guangxi Population Health Information Business Application Platform. The analysis included women with two consecutive singleton deliveries between 2018 and 2023 from 81 medical institutions in Nanning City, Guangxi Zhuang Autonomous Region. Maternal demographic characteristics and delivery outcome data were collected. The association between IPI and preterm birth was assessed using logistic regression model, with subgroup analyses stratified by maternal age, mode of delivery, and preterm birth (all in the previous pregnancy). Additionally, a restricted cubic spline model was applied to examine the dose-response relationship between IPI and the risk of preterm birth. Results: A total of 39 434 women with two consecutive singleton pregnancies and deliveries were included in this study. Of these, 2 055 (5.2%) experienced a preterm birth in the subsequent delivery. Compared with an IPI of 18-23 months, the risk of preterm birth was significantly increased by 90% (OR=1.90, 95%CI: 1.53-2.33) for IPI <6 months and by 21% (OR=1.21, 95%CI: 1.04-1.41) for IPI of 6-11 months. This significantly elevated risk associated with short IPIs was observed across most subgroups. Among women with an IPI of ≥36 months, those who delivered vaginally had a 30% (OR=1.30, 95%CI: 1.04-1.63) increased risk of preterm birth. Restricted cubic spline analysis revealed an L-shaped dose-response relationship between IPI and the risk of preterm birth. The lowest risk was observed with IPIs ranging from 16 to 27 months. Conclusions: A short IPI is a risk factor for preterm birth. When providing preconception medical services across different populations, greater emphasis should be placed on assessing maternal age, prior pregnancy, and delivery history. Additionally, postpartum care should include personalized guidance to maintain an optimal IPI, thereby reducing the risk of preterm birth and improving maternal and infant health outcomes.
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