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Assessing Visual Function in Retinal Gene Therapy
Andrew J Anderson1, Michael Bach2, Ruth E Hogg3
1Department of Optometry and Vision Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia. aaj@unimelb.edu.au.
Methods in Molecular Biology (Clifton, N.J.)
|April 22, 2026
Summary
This study introduces three computerized tests to measure light detection, localization, and motion in individuals with severe vision loss. These accessible tests offer a new way to assess visual function in challenging cases, like after retinal gene therapy.
Area of Science:
- Ophthalmology
- Neuroscience
- Biomedical Engineering
Background:
- Standard visual function tests are unsuitable for profound vision loss.
- Retinal gene therapy may involve patients with severe visual impairment.
Purpose of the Study:
- To provide instructions for a battery of computerized tests.
- To quantify light detection, localization, and motion in eyes with profound vision loss.
Main Methods:
- Developed three computerized tests.
- Tests utilize conventional computer hardware.
- Minimal calibration required, short performance time.
Main Results:
- Successfully quantified light detection, localization, and motion.
- Demonstrated feasibility in eyes with profound vision loss.
Conclusions:
- The computerized test battery is a practical tool for assessing visual function in severe vision loss.
- These tests are valuable for evaluating outcomes in retinal gene therapy and other conditions causing profound visual impairment.
