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Related Experiment Video

Updated: Apr 24, 2026

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Published on: November 2, 2018

Assessing Visual Function in Retinal Gene Therapy.

Andrew J Anderson¹, Michael Bach², Ruth E Hogg³

¹Department of Optometry and Vision Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia. aaj@unimelb.edu.au.

Methods in Molecular Biology (Clifton, N.J.)

|April 22, 2026

Summary

This summary is machine-generated.

This study introduces three computerized tests to measure light detection, localization, and motion in individuals with severe vision loss. These accessible tests offer a new way to assess visual function in challenging cases, like after retinal gene therapy.

Keywords:

Detection Localization Motion Retinal gene therapy Sensitivity Vision testing Visual function

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Area of Science:

Ophthalmology
Neuroscience
Biomedical Engineering

Background:

Standard visual function tests are unsuitable for profound vision loss.
Retinal gene therapy may involve patients with severe visual impairment.

Purpose of the Study:

To provide instructions for a battery of computerized tests.
To quantify light detection, localization, and motion in eyes with profound vision loss.

Main Methods:

Developed three computerized tests.
Tests utilize conventional computer hardware.
Minimal calibration required, short performance time.

Main Results:

Successfully quantified light detection, localization, and motion.
Demonstrated feasibility in eyes with profound vision loss.

Conclusions:

The computerized test battery is a practical tool for assessing visual function in severe vision loss.
These tests are valuable for evaluating outcomes in retinal gene therapy and other conditions causing profound visual impairment.