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    Major depressive disorder (MDD) is a significant global health issue. This review highlights accurate diagnosis and effective pharmacologic treatments for adults, recommending personalized care for better outcomes.

    Keywords:
    SNRIsSSRIsadjunctive therapiesaripiprazolebrexpiprazoledepressionmajor depressive disorder (MDD)treatment-resistant major depressive disorder

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    Area of Science:

    • Psychiatry and Mental Health
    • Clinical Medicine
    • Pharmacology

    Background:

    • Major depressive disorder (MDD) is a leading cause of global disability and mortality.
    • It represents a substantial burden within industrialized nations' mental health landscape.
    • Effective management strategies are crucial for patient well-being.

    Purpose of the Study:

    • To review and emphasize accurate diagnosis of MDD in adults.
    • To discuss effective pharmacologic treatment and management of MDD.
    • To recommend an optimal approach for patient care and recovery.

    Main Methods:

    • This is a review article, synthesizing existing literature.
    • Focuses on diagnostic criteria for MDD.
    • Examines pharmacologic interventions and management strategies.

    Main Results:

    • Accurate diagnosis is paramount for effective MDD management.
    • Pharmacologic treatments offer viable options for symptom control.
    • Individualized care plans are essential for addressing MDD complexity.

    Conclusions:

    • A timely and individualized approach to MDD care is recommended.
    • Addressing the complexity of MDD can improve patient recovery.
    • Effective management involves accurate diagnosis and tailored pharmacologic treatment.