Related Experiment Video
Updated: Apr 24, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
Published on: November 10, 2014
A Case of Primary Endobronchial Hyalinizing Clear Cell Carcinoma Presenting as an Oncologic Emergency Due to Complete
Shoichiro Matsumoto1, Yuki Takigawa1, Ken Sato1
1Department of Respiratory Medicine, NHO Okayama Medical Center, Japan.
Abstract:
A 66-year-old man presented with dyspnea and severe hypoxemia, requiring mechanical ventilation. Computed tomography revealed an obstruction of the left main bronchus by a bronchial tumor, thus prompting airway intervention to relieve the stenosis. A histopathological examination of the tumor revealed clear cytoplasm and hyalinized stroma, and rearrangement of EWSR1 was detected by a fluorescence in situ hybridization analysis. Comprehensive genomic profiling was performed because of the rarity of this case. GenMineTOP, capable of detecting the EWSR1::ATF1 fusion, contributed to a definitive diagnosis of hyalinizing clear cell carcinoma. Bronchoscopic airway intervention can serve as both a therapeutic and diagnostic procedure; GenMineTOP was useful in establishing a definitive diagnosis.
Related Concept Videos
Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques
Endoscopic Studies I: Bronchoscopy and Thoracoscopy
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
Endotracheal Intubation I: Procedure
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Cardiopulmonary Resuscitation II: ACLS Airway Management
Trachea
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of...

