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Published on: May 5, 2018
The impact of gestational diabetes mellitus on neonatal cardiac development
Lina Qi1, Lifen Yuan1, Junsheng Jiang1
1Pediatrics, https://ror.org/059cjpv64The Second Affiliated Hospital of Zhejiang University Linping Campus, Hangzhou, China.
Objective:
To investigate the effect of maternal gestational diabetes mellitus (GDM) on neonatal cardiac development.
Methods:
A retrospective analysis of full-term newborns admitted in 2024 was conducted. 100 newborns of mothers with GDM (IADPSG criteria) were the GDM group, and 100 of non-GDM mothers were the control group. We compared their birth parameters,echocardiographic indicators and congenital heart disease (CHD) incidence, and analyzed factors related to neonatal interventricular septal (IVS) hypertrophy.
Results:
The GDM group had significantly higher birth weight, length and placental weight (P < 0.05); echocardiography showed larger cardiac chambers, great vessels and thicker IVS (P > 0.05); CHD incidence was 2% (vs. 0% in control, P = 0.047). Maternal glycemic indicators and neonatal birth weight were positively correlated with IVS thickness (P < 0.05).
Conclusion:
GDM adversely affects neonatal cardiac development; routine fetal and postnatal cardiac evaluation is necessary for GDM pregnancies. Further research is needed to clarify mechanisms and establish monitoring strategies.
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