Association of Systemic Inflammation Response Index With All-Cause and Cardiovascular Mortality Among Individuals...

The Systemic Inflammation Response Index (SIRI) has recently been investigated as a new marker of inflammation. This study investigated the association between SIRI and all-cause and cardiovascular mortality risks in patients with depression.

Based on data from the National Health and Nutrition Examination Survey (NHANES), 2410 participants with depression were included and followed up for all-cause and cardiovascular-related deaths through December 31, 2019. Depression was identified as a 9-item Patient Health Questionnaire (PHQ-9) score ≥10. Weighted multivariate Cox proportional hazards regression analyses assessed the relationship between SIRI and all-cause and cardiovascular mortality. Time-dependent receiver operating characteristic (ROC) curve analysis evaluated SIRI's accuracy in predicting survival outcomes.

Among the 2410 participants, 282 all-cause death events and 84 cardiovascular disease (CVD)-related death events were documented. In the fully adjusted models, the highest SIRI tertile was significantly associated with increased risk of all-cause and cardiovascular mortality with hazard ratios (HRs) (95% CIs) of 1.26 (0.79, 2.02) for all-cause mortality and 2.50 (1.22, 5.13) for cardiovascular mortality. This association remained consistent in subgroup and sensitivity analyses. The time-dependent ROC curve showed that the areas under the curve of the 3-, 5-, and 10-year survival rates were 0.702, 0.692, and 0.644 for all-cause mortality, and 0.685, 0.714, and 0.653 for cardiovascular mortality, respectively.

An elevated SIRI is associated with an increased risk of all-cause and cardiovascular mortality among patients with depression.