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Updated: Apr 24, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Evaluation of epicardial adipose tissue in children with chronic kidney disease

Mehmet Baha Aytac, Mustafa Dogan, Sule Ayas Ergul

    Clinical Nephrology
    |April 23, 2026
    PubMed

    Insights

    Epicardial adipose tissue was lower in children with chronic kidney disease, but did not predict cardiovascular disease risk. Further research is needed to validate epicardial adipose tissue thickness as a cardiovascular disease predictor in pediatric chronic kidney disease.

    Area of Science:

    • Pediatric Nephrology
    • Cardiovascular Research
    • Echocardiography

    Background:

    • Epicardial adipose tissue (EAT) is a predictor of cardiovascular disease (CVD) in adults with diabetes, obesity, and chronic kidney disease (CKD).
    • The role of EAT in predicting CVD risk in children with CKD is not well-established.

    Purpose of the Study:

    • To evaluate epicardial adipose tissue (EAT), carotid intima-media thickness (CIMT), and left ventricular mass index (LVMI) in children with CKD.
    • To compare these parameters with those of healthy children.

    Main Methods:

    • A case-control study involving 23 children with CKD and 21 age- and sex-matched healthy controls.
    • Transthoracic echocardiography was used to measure EAT, CIMT, and LVMI.
    • Demographic and biochemical parameters were also compared.

    Main Results:

    • No significant differences in age, weight, height, BMI, blood pressure, glucose, calcium, phosphorus, or lipid levels were found between groups.
    • Children with CKD had lower EAT thickness (6.45 ± 1.61 mm) compared to controls (7.70 ± 1.69 mm, p < 0.05).
    • No significant difference in CIMT was observed between patients and controls (0.40 vs. 0.42 mm, p = 0.29).

    Conclusions:

    • Lower epicardial adipose tissue thickness in children with CKD warrants further investigation.
    • Current findings suggest that EAT thickness may not be a reliable predictor of CVD in pediatric CKD.
    • Larger, long-term studies are needed to determine the utility of EAT thickness for CVD risk estimation in pediatric CKD.
    Abstract

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